Alessia Lodi Selected Research

IACS-010759

1/2022	Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia.
1/2021	The Combined Treatment With the FLT3-Inhibitor AC220 and the Complex I Inhibitor IACS-010759 Synergistically Depletes Wt- and FLT3-Mutated Acute Myeloid Leukemia Cells.
1/2018	An inhibitor of oxidative phosphorylation exploits cancer vulnerability.

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Alessia Lodi Research Topics

Disease

18	Neoplasms (Cancer) 05/2022 - 01/2009
6	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 04/2022 - 02/2011
4	Leukemia 01/2020 - 02/2011
4	Prostatic Neoplasms (Prostate Cancer) 01/2020 - 03/2013
4	Breast Neoplasms (Breast Cancer) 10/2017 - 01/2011
3	Inflammation (Inflammations) 01/2019 - 11/2014
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2022 - 01/2020
2	Carcinogenesis 01/2020 - 05/2014
2	Brain Neoplasms (Brain Tumor) 01/2018 - 11/2017
2	Hypoxia (Hypoxemia) 01/2018 - 02/2011
2	Disease Progression 11/2017 - 01/2013
2	Rheumatoid Arthritis 01/2016 - 01/2016
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022
1	Obesity 01/2021
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021
1	Hypertrophy 01/2021
1	Insulin Resistance 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2018
1	Arthritis (Polyarthritis) 01/2016
1	Pancreatitis 11/2014
1	Metaplasia 11/2014
1	Pancreatic Neoplasms (Pancreatic Cancer) 11/2014
1	Melanoma (Melanoma, Malignant) 06/2014
1	Multiple Myeloma 01/2013
1	Mitochondrial Diseases (Mitochondrial Disease) 02/2011

Drug/Important Bio-Agent (IBA)

4	Pharmaceutical PreparationsIBA 05/2022 - 02/2011
3	IACS-010759IBA 01/2022 - 01/2018
3	Glutamine (L-Glutamine)FDA Link 01/2022 - 11/2016
3	EnzymesIBA 01/2022 - 05/2014
2	IsotopesIBA 05/2022 - 08/2020
2	venetoclaxIBA 04/2022 - 01/2022
2	GlutaminaseIBA 01/2022 - 11/2016
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 01/2009
2	NucleotidesIBA 01/2018 - 05/2014
2	Glucose (Dextrose)FDA LinkGeneric 01/2016 - 01/2016
2	Biomarkers (Surrogate Marker)IBA 11/2014 - 01/2013
2	Lactic Acid (Lactate)FDA LinkGeneric 11/2014 - 03/2013
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 06/2014 - 03/2013
2	U 0126 (UO 126)IBA 06/2014 - 03/2013
1	CB-839IBA 05/2022
1	Docetaxel (Taxotere)FDA Link 05/2022
1	Asparaginase (Elspar)FDA Link 01/2022
1	Protein Tyrosine PhosphatasesIBA 01/2021
1	Insulin ReceptorIBA 01/2021
1	Drug CombinationsIBA 12/2020
1	Therapeutic UsesIBA 12/2020
1	Methionine (L-Methionine)FDA Link 01/2020
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2020
1	shikoninIBA 01/2020
1	purineIBA 01/2020
1	PhytochemicalsIBA 01/2020
1	pyrimidineIBA 01/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019
1	Choline KinaseIBA 01/2019
1	Bevacizumab (Avastin)FDA Link 01/2018
1	Alkylating AgentsIBA 01/2018
1	Aspartic Acid (Aspartate)FDA Link 01/2018
1	isophosphamide mustard (IPAM)IBA 01/2018
1	ProdrugsIBA 01/2018
1	TH 302IBA 01/2018
1	Serotonin (5 Hydroxytryptamine)IBA 10/2017
1	5-nonyloxytryptamineIBA 10/2017
1	Tryptamines (Triptans)IBA 10/2017
1	Serotonin Receptor Agonists (Serotonin Receptor Agonist)IBA 10/2017
1	Ursolic AcidIBA 01/2017
1	CurcuminIBA 01/2017
1	ResveratrolIBA 01/2017
1	IsoenzymesIBA 11/2016
1	Protein Isoforms (Isoforms)IBA 11/2016
1	Methotrexate (Mexate)FDA LinkGeneric 01/2016
1	Messenger RNA (mRNA)IBA 01/2016
1	Rituximab (Mabthera)FDA Link 01/2016
1	Taurine FDA Link 11/2014
1	LipopolysaccharidesIBA 11/2014
1	LipidsIBA 11/2014
1	Phosphorylcholine (Phosphocholine)IBA 06/2014
1	Nucleic AcidsIBA 05/2014
1	NexusIBA 05/2014
1	Proteins (Proteins, Gene)FDA Link 05/2014
1	Pyruvic Acid (Pyruvate)IBA 03/2013
1	Mitogen-Activated Protein KinasesIBA 03/2013
1	Protons (Proton)IBA 01/2013
1	Oxygen (Dioxygen)IBA 02/2011
1	Indomethacin (Indometacin)FDA LinkGeneric 02/2011
1	Phospholipids (Phosphatides)FDA LinkGeneric 02/2011
1	Aldo-Keto ReductasesIBA 02/2011
1	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- oneIBA 01/2011
1	Citric Acid (Citrate)FDA LinkGeneric 01/2011
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2011
1	tanespimycin (17AAG)IBA 01/2011
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2011
1	Medroxyprogesterone Acetate (Depo-Provera)FDA LinkGeneric 01/2009
1	BezafibrateIBA 01/2009

Therapy/Procedure

7	Therapeutics 12/2020 - 01/2011
2	Drug Therapy (Chemotherapy) 01/2022 - 01/2016
1	Chemoprevention 01/2020